Our Science

 

Approach

AnTolRx is revolutionizing the treatment of autoimmune diseases through the development of novel, targeted therapeutics utilizing specific self-antigens and unique tolerogenic molecules to actively promote immune tolerance. Our patented nanotechnology is designed induce antigen specific immune tolerance.

Our nano formulations incorporate two integral aspects which work together to send a strong therapeutic signal:

  1. Signal 1 : Tolerance Molecule
    The tolerogenic molecule is designed to induce a strong anti-inflammatory signal and promote tolerance to our desired antigen. Such molecules include ligands of the aryl hydrocarbon receptor (AHR) which induces immune tolerance through the induction of anti-inflammatory pathways and the suppression of pro-inflammatory signals.
  2. Signal 2 : Antigen
    The antigen is the target of our tolerogenic signal and can be a protein, peptide, or collection of peptides. With the versatility of our nano formulation system, this component can be customized to target antigens relevant to any autoimmune disease.

Pipeline

We are rapidly advancing a potential therapy for the treatment of Type 1 Diabetes through partnerships with Pfizer, Inc. and JDRF and are advancing pre-clinical programs in a number of other auto-immune related diseases, including Rheumatoid Arthritis, Psoriasis, Inflammatory Bowel Disease, Celiac Disease, Myasthenia Gravis, and Multiple Sclerosis.