News
PublicationsThe aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease.
Rothhammer, V. and Quintana, F. Nat Rev Immunol. (2019)
AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice.
Goettel, J. et al. Cell Rep 17, 1318-1329(2016)
Tolerogenic nanoparticles inhibit T cell-mediated autoimmunity through SOCS2.
Yeste, A. et al. Sci Signal 9, ra61(2016)
IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.
Mascanfroni, I. D. et al. Nat Immunol 14, 1054–1063 (2013).
Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis.
Yeste, A., Nadeau, M., Burns, E. J., Weiner, H. L. & Quintana, F. J. Proc Natl Acad Sci USA 109, 11270–11275 (2012).
An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis.
Quintana, F. J. et al. Proc Natl Acad Sci USA 107, 20768–20773 (2010).
Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells.
Gandhi, R. et al. Nat Immunol 11, 846–853 (2010).
The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27.
Apetoh, L. et al. Nat Immunol 11, 854 (2010).
Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor
Quintana, F. J. et al. Nature 453, 65–71 (2008).